abstract：:The present study aimed to ascertain whether suppression of midkine (MK) expression in pancreatic cancer cells inhibits metastasis to the liver. Human pancreatic cancer AsPC-1 cells were transfected with small interfering RNA (siRNA) targeting MK. siRNA against MK was observed to reduce the expression of MK mRNA and p...

journal_title：Oncology letters

authors： Yu L,Fan Y,Chen B,Hu Y,Gao Y,Wei D

更新日期：2013-11-01 00:00:00

abstract：:CD133+ tumor cells have a greater potential ability for tumorigenesis, proliferation, invasion and metastasis compared with CD133- tumor cells. Ki-67 is associated with cell proliferation in various tumors and has a markedly positive correlation with the prognosis of patients. However, there are a limited number of st...

journal_title：Oncology letters

authors： Lu C,Liu L,Wu X,Xu W

更新日期：2013-11-01 00:00:00

abstract：:Radiation enterocolitis is a severe adverse event that occurs after radiotherapy for malignant abdominal tumors. In this study, the therapeutic effects of ETS-GS, a novel vitamin E derivative with antioxidative and anti-inflammatory abilities, were examined in a rat model of radiation enterocolitis. The radiation ente...

journal_title：Oncology letters

authors： Sugita S,Inomata M,Kono Y,Shiroshita H,Etoh T,Shiraishi N,Kitano S

更新日期：2013-11-01 00:00:00

abstract：:Vasculogenic mimicry (VM), a new pattern of tumor microcirculation, is important for the growth and progression of tumors. Epithelial-mesenchymal transition (EMT) is pivotal in malignant tumor progression and VM formation. With increasing knowledge of cancer stem cell (CSC) phenotypes and functions, increasing evidenc...

journal_title：Oncology letters

authors： Fan YL,Zheng M,Tang YL,Liang XH

更新日期：2013-11-01 00:00:00

abstract：:Golgi protein 73 (GP73) is a resident Golgi type II transmembrane protein that has been reported to markedly increase in chronic liver disease, particularly in hepatocellular carcinoma (HCC). However, it remains unclear as to whether serum GP73 represents a reliable serum marker for the diagnosis of HCC. The aim of th...

journal_title：Oncology letters

authors： Hou SC,Xiao MB,Ni RZ,Ni WK,Jiang F,Li XY,Lu CH,Chen BY

更新日期：2013-10-01 00:00:00

abstract：:An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...

journal_title：Oncology letters

authors： Wen SL,Zhang F,Feng S

更新日期：2013-10-01 00:00:00

abstract：:In the present study, a low molecular weight polysaccharide, ABP-AW1, isolated from Agaricus blazei Murill was assessed for its potential adjuvant activity. ABP-AW1 is considered to create a 'depot' of antigen at a subcutaneous injection site. ICR mice were immunized with 100 μg ovalbumin (OVA) alone or with 100 μg OV...

journal_title：Oncology letters

authors： Cui L,Sun Y,Xu H,Xu H,Cong H,Liu J

更新日期：2013-10-01 00:00:00

abstract：:Askin tumors are rare malignant neoplasms that are localized in the thoracopulmonary region and mainly occur in children and adolescents. Further investigation with regard to the effective treatment of this disease is required, since the disease has a low incidence and limited knowledge is available on the biological ...

journal_title：Oncology letters

authors： Dou X,Yan H,Wang R

更新日期：2013-10-01 00:00:00

abstract：:Carbon dioxide (CO2) laser ablation in combination with photodynamic therapy (PDT) has previously been successfully used to treat superficial basal cell carcinoma (BCC). However, the efficacy of this treatment modality is limited in the treatment of deeper lesions and the more aggressive subtypes of BCC. In order to i...

journal_title：Oncology letters

authors： Kim SA,Lee KS,Cho JW

更新日期：2013-10-01 00:00:00

abstract：:Taxanes, including paclitaxel (PTX) and docetaxel (DOC), are poorly soluble in water due to their hydrophobic properties and thus, require solvents. However, use of these solvents has been associated with toxic responses, including a hypersensitivity reaction (HSR). Nanoparticle albumin-bound paclitaxel (nab-PTX) is a...

journal_title：Oncology letters

authors： Kimura K,Tanaka S,Iwamoto M,Fujioka H,Takahashi Y,Sato N,Terasawa R,Tominaga T,Ikari A,Uchiyama K

更新日期：2013-10-01 00:00:00

abstract：:A 54-year-old female presented with a large pancreatic tumor of the tail during a regular physical examination. The patient underwent surgical intervention and the surgeon identified that the tumor originated from the retroperitoneal region. Markedly severe hemodynamic fluctuations occurred during the manipulation of ...

journal_title：Oncology letters

authors： Huang YH,Liaw WJ,Kuo CP,Wu ZF,Cherng CH,Yu JC,Horng HC,Huang ST

更新日期：2013-09-01 00:00:00

abstract：:The aim of the present study was to determine the efficacy of microsurgery treatment for parasagittal meningioma in the central gyrus region. A microsurgical technique was used to treat 26 patients with large parasagittal meningioma in the central gyrus region. The Rolandic and draining veins and the peritumoral norma...

journal_title：Oncology letters

authors： Bi N,Xu RX,Liu RY,Wu CM,Wang J,Chen WD,Liu J,Xu YS,Wei ZQ,Li T,Zhang J,Bai JY,Dong B,Fan SJ,Xu YH

更新日期：2013-09-01 00:00:00

abstract：:Metaplastic carcinoma of the breast refers to a heterogenous group of mammary carcinomas that contain a mixture of various cell types, including squamous cells, spindle cells and/or a mesenchymal component, such as bone or cartilage. To the best of our knowledge, the clinical course of a tumour that has undergone a tr...

journal_title：Oncology letters

authors： Chuthapisith S,Warnnissorn M,Amornpinyokiat N,Pradniwat K,Angsusinha T

更新日期：2013-09-01 00:00:00

abstract：:Changes in filamin A (FLNa) expression contribute to the development and progression of numerous malignancies. However, in vitro studies of breast cancer have shown conflicting results. Thus, the present study aimed to detect the expression of FLNa in breast cancer tissue samples and the association with clinicopathol...

journal_title：Oncology letters

authors： Tian HM,Liu XH,Han W,Zhao LL,Yuan B,Yuan CJ

更新日期：2013-09-01 00:00:00

abstract：:Percutaneous transluminal angioplasty using balloon catheters for Budd-Chiari syndrome (BCS) and transcatheter arterial chemoembolization (TACE) for unresectable hepatocellular carcinoma (HCC) have become increasingly accepted as alternative therapeutic modalities. However, few studies have investigated the clinical e...

journal_title：Oncology letters

authors： Zhang QQ,Zu MH,Xu H,Gu YM,Wang WL,Gao ZK

更新日期：2013-08-01 00:00:00

abstract：:Sarcomatoid carcinomas exhibit features that are common to epithelial and mesenchymal tumors. These carcinomas are rare, particularly in the small intestine. In the current case report, we describe a case of an intestinal sarcomatoid carcinoma in a 70-year-old Chinese female. Sarcomatoid carcinoma was confirmed based ...

journal_title：Oncology letters

authors： Han N,Han QH,Liu YZ,Li ZC,Li J

更新日期：2013-08-01 00:00:00

abstract：:In previous studies we observed that rhein lysinate (RHL), a salt of rhein and lysine that is easily dissolved in water, inhibited the growth of tumor cells in breast cancer, ovarian cancer, hepatocellular carcinoma and cervical cancer. The present study aimed to investigate the effects of RHL on H460 and A549 non-sma...

journal_title：Oncology letters

authors： Zhen YZ,Hu G,Zhao YF,Yan F,Li R,Gao JL,Lin YJ

更新日期：2013-08-01 00:00:00

abstract：:The Na+/K+-ATPase α subunit is highly expressed in malignant cells. Ouabain, a cardioactive glycoside, binds to the Na+/K+-ATPase α subunit and inhibits the activity of Na+/K+-ATPase. In the present study, the effect of ouabain on the migration of A549 cells was analyzed using the wound healing and transwell chamber m...

journal_title：Oncology letters

authors： Liu N,Li Y,Su S,Wang N,Wang H,Li J

更新日期：2013-08-01 00:00:00

abstract：:The aim of this study was to ensure a high dose of intensity modulated radiation therapy (IMRT) was delivered to tumor tissue with a low dose to normal organs. Seldinger interventional techniques were used to inject chemotherapy drugs for nasopharyngeal carcinoma (NPC). IMRT was conducted 3 weeks after intervention. P...

journal_title：Oncology letters

authors： Fen X,Qin W,Bao W,Jiang F,Li B,Hu F,Chen X

更新日期：2013-08-01 00:00:00

abstract：:microRNAs (miRNAs) have been hypothesized to function as oncogenes or tumor suppressors by targeting specific cancer-related genes. Previous studies have reported that miR-223 may serve as a tumor suppressor in a number of cancer types, however, knowledge of its targets in non-small cell lung cancer (NSCLC) remains li...

journal_title：Oncology letters

authors： Nian W,Ao X,Wu Y,Huang Y,Shao J,Wang Y,Chen Z,Chen F,Wang D

更新日期：2013-08-01 00:00:00

abstract：:Current endocrine therapies for females with estrogen receptor-positive breast cancer have facilitated substantial improvements in outcomes. The effectiveness of endocrine therapy is limited by either initial de novo resistance or acquired endocrine resistance. Multiple mechanisms responsible for endocrine resistance ...

journal_title：Oncology letters

authors： Zhou J,Teng R,Wang Q,Xu C,Guo J,Yuan C,Shen J,Hu W,Wang L,Xie S

更新日期：2013-08-01 00:00:00

abstract：:The present study aimed to evaluate the expression of hypoxia-inducible factor-1α (HIF-1α) and MDR1/P-glycoprotein (P-gp) in human laryngeal squamous cell carcinoma (LSCC) tissues, and also to investigate the regulation of MDR1 gene expression by HIF-1α in Hep-2 cells under hypoxic conditions. The expression of HIF-1α...

journal_title：Oncology letters

authors： Xie J,Li DW,Chen XW,Wang F,Dong P

更新日期：2013-07-01 00:00:00

abstract：:Malignant mesothelioma in the mediastinum is rare and the majority of known cases have been reported as 'localized mesothelioma'. The present study reports a case of an upper mediastinal tumor, which was diagnosed through thoracoscopic surgery and surgical biopsies of the mass. A computed tomography scan revealed a gi...

journal_title：Oncology letters

authors： Zhang S,Song P,Zhang B

更新日期：2013-07-01 00:00:00

abstract：:The present study aimed to evaluate the expression of p53, Ki-67, epidermal growth factor receptor (EGFR) and O6-methylguanine-DNA methyltransferase (MGMT), and to analyze the correlation between their expression and the histological grade of the tumors in 152 patients with gliomas. The tumors were classified accordin...

journal_title：Oncology letters

authors： Hu X,Miao W,Zou Y,Zhang W,Zhang Y,Liu H

更新日期：2013-07-01 00:00:00

abstract：:TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

journal_title：Oncology letters

authors： Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

更新日期：2013-07-01 00:00:00

abstract：:The aim of the present study was to detect the amplification of the human epidermal growth factor receptor 2 (HER2) gene in esophageal squamous cell carcinoma (ESCC), gastroesophageal junction adenocarcinoma (GEJAC) and gastric cancer (GC), as well as to understand the pathological meaning of HER2 gene amplification w...

journal_title：Oncology letters

authors： Huang JX,Zhao K,Lin M,Wang Q,Xiao W,Lin MS,Yu H,Chen P,Qian RY

更新日期：2013-07-01 00:00:00

abstract：:[This corrects the article on p. 43 in vol. 4, PMID: 22807957.]. ...

journal_title：Oncology letters

authors：

更新日期：2013-06-01 00:00:00

abstract：:The aim of the present study was to identify a specific biological marker for the diagnosis of colorectal adenomas through the analysis of variations in serum protein profiling in colorectal adenoma patients. The study was conducted at the Renmin Hospital of Wuhan University (Wuhan, China) between September 2011 and M...

journal_title：Oncology letters

authors： Zhou ZY,Tao DD,Cao JW,Luo HS

更新日期：2013-06-01 00:00:00

abstract：:Docetaxel is the current first-line treatment for castration-resistant prostate cancer (CRPC), following failure to respond to maximal androgen blockade (MAB). Patients who fail to respond to docetaxel may receive cabazitaxel or abiraterone; however, there are no recommendations on which of these two agents should be ...

journal_title：Oncology letters

authors： Marech I,Vacca A,Sivestris N,Gnoni A,Lorusso V

更新日期：2013-06-01 00:00:00

abstract：:Angiomatoid fibrous histiocytoma (AFH) is a rare, low-grade malignant potential soft tissue tumor which occurs most commonly in children and young adults. Only a few case reports have been described that typically occur in the extremities of the deep dermis and subcutaneous tissue, followed by the trunk, as well as th...

journal_title：Oncology letters

authors： Xiang L,Zhou J,Gu W,Yang B

更新日期：2013-06-01 00:00:00

abstract：:It is well-known that tumor angiogenesis is important in cancer development, and studies on blocking angiogenesis to treat tumors have become one of the most promising and active fields in anticancer research. The present study investigated the effect of siRNA targeting the tyrosine kinase receptor 2 (Tie2) gene in co...

journal_title：Oncology letters

authors： Guo F,Xun Q,Zhou H

更新日期：2013-06-01 00:00:00

abstract：:Giant osteomas of the ethmoid and frontal sinuses ary very rare, with only a few dozen cases reported in the literature. Given their rarity, the clinical characteristics and treatment of this disease remain controversial. In this study, the clinical presentation and surgical methods used to treat three patients with g...

journal_title：Oncology letters

authors： Cheng KJ,Wang SQ,Lin L

更新日期：2013-05-01 00:00:00

abstract：:No standard therapy for pulmonary epithelioid hemangioendothelioma (PEH) has yet been established due to the rarity of the disease, the lack of clear standards for treatment and the partial-to-complete spontaneous regression. This report describes three cases of PHE manifested as bilateral intrapulmonary masses with a...

journal_title：Oncology letters

authors： Ye B,Li W,Feng J,Shi JX,Chen Y,Han BH

更新日期：2013-05-01 00:00:00

abstract：:Polymorphisms of the vitamin D receptor (VDR) gene may be a risk factor for pancreatic cancer (PC). We investigated the association of two single-nucleotide polymorphisms (SNPs) of the VDR gene with PC in age- and gender-matched patients and controls. PC (n=91) and healthy control (n=80) samples were genotyped for the...

journal_title：Oncology letters

authors： Li L,Wu B,Yang L,Yin G,Wei W,Sui S,Liu J

更新日期：2013-05-01 00:00:00

abstract：:Toll-like receptor-9 (TLR9) is a member of the innate immune system and recognizes bacterial and vertebrate DNA in cells. In addition to being expressed in cells of the immune system, it is widely expressed in various types of human cancer, including prostate cancer. We have previously demonstrated that synthetic TLR9...

journal_title：Oncology letters

authors： Väisänen MR,Jukkola-Vuorinen A,Vuopala KS,Selander KS,Vaarala MH

更新日期：2013-05-01 00:00:00

abstract：:The aim of the present study was to investigate the association between the expression of chemokine receptors CCR7 and CXCR4 and vascular endothelial growth factor (VEGF)-C and the lymph node metastasis of pancreatic ductal adenocarcinoma (PDAC). The mRNA transcription levels of CCR7, CXCR4 and VEGF-C were measured in...

journal_title：Oncology letters

authors： Guo J,Lou W,Ji Y,Zhang S

更新日期：2013-05-01 00:00:00

abstract：:Rare types of cancer are often not effectively treated by approaches such as chemotherapy and radio-therapy, although their side-effects persist. Immunotherapy has been gaining attention worldwide with growing examples of its anticancer activity demonstrated in vivo. This case report describes a 35-year-old male who s...

journal_title：Oncology letters

authors： Ratnavelu K,Subramani B,Pullai CR,Krishnan K,Sugadan SD,Rao MS,Veerakumarasivam A,Deng X,Hiroshi T

更新日期：2013-05-01 00:00:00

abstract：:Local adjuvant treatment of giant cell tumours (GCTs) of the bone with phenol has led to a significant reduction in recurrence rates. In the current study, the optimal phenol concentration and duration of intralesional exposure were evaluated. Specimens of GCTs were exposed to various concentrations of phenol solution...

journal_title：Oncology letters

authors： Mittag F,Leichtle C,Kieckbusch I,Wolburg H,Rudert M,Kluba T,Leichtle U

更新日期：2013-05-01 00:00:00

abstract：:Pulmonary sequestration (PS) is an uncommon lung disease. Carcinoid tumorlets in pulmonary sequestration are extremely rare. This case report presents a rare clinical case of carcinoid tumorlet in pulmonary sequestration with bronchiectasis after breast cancer. A 64-year-old female was diagnosed with infiltrating duct...

journal_title：Oncology letters

authors： Ye Y,Mu Z,Wu D,Xie Y

更新日期：2013-05-01 00:00:00

abstract：:The aim of this study was to investigate the correlation between Girdin and PI3K in breast cancer stem cells and the clinical implications of the co-expression of these two proteins in breast cancer patients. CD44+/CD24- tumor cells from the MD-231 cell line were sorted by flow cytometry. The expression status of Gird...

journal_title：Oncology letters

authors： Jin F,Liu C,Guo Y,Chen H,Wu Y

更新日期：2013-05-01 00:00:00